Ebola virus (EBOV) infection: Therapeutic strategies

Ebola virus outbreak, updates on current therapeutic strategies.

Filoviruses are enveloped negative-sense single-stranded RNA viruses, which include Ebola and Marburg viruses, known to cause hemorrhagic fever in humans with a case fatality of up to 90%. There have been several Ebola virus outbreaks since the first outbreak in the Democratic Republic of Congo in 1976 of which, the recent 2013-2015 epidemic in Guinea, Liberia, and Sierra Leone is the largest i...

Ebola virus infection

Ebola virus-like particles protect from lethal Ebola virus infection.

The filovirus Ebola causes hemorrhagic fever with 70-80% human mortality. High case-fatality rates, as well as known aerosol infectivity, make Ebola virus a potential global health threat and possible biological warfare agent. Development of an effective vaccine for use in natural outbreaks, response to biological attack, and protection of laboratory workers is a higher national priority than e...

Estimating the Reproduction Number of Ebola Virus (EBOV) During the 2014 Outbreak in West Africa

The 2014 Ebola virus (EBOV) outbreak in West Africa is the largest outbreak of the genus Ebolavirus to date. To better understand the spread of infection in the affected countries, it is crucial to know the number of secondary cases generated by an infected index case in the absence and presence of control measures, i.e., the basic and effective reproduction number. In this study, I describe th...

Lactating mothers infected with Ebola virus: EBOV RT-PCR of blood only may be insufficient.

M Moreau ([email protected])1,2, C Spencer2,3, J G Gozalbes2, R Colebunders4,5, A Lefevre2,6, S Gryseels7,8, B Borremans7,8, S Gunther7,9, D Becker7,10, J A Bore7, F R Koundouno7, A Di Caro7,11, R Wölfel7,12, T Decroo13, M Van Herp13, L Peetermans14, A M Camara15 1. Department of Emergency Medicine, Centre Hospitalier Chrétien, Liège, Belgium 2. Médecins Sans Frontières, Operational Centre B...